1. Easy build via MacPorts
For Snow Leopard users, you can build OpenCV 2.1.0 and above via MacPorts as a 64-bit library with support of QTKit video I/O and Cocoa GUI.
Assuming MacPorts installed, first use:
sudo port selfupdate
to update the MacPorts base and the port tree. Then, simply:
sudo port install opencv
to build OpenCV 2.1.0 in 64-bit.
Mac_OS_X_OpenCV_Port - OpenCV Wiki